GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| BRCA | cis | rs13393800 | 1 | rs1307667 | chr2:233419972 | EIF4E2 | chr2:233415357-233448349:+ | -0.17 | -3.96 | 7.93E-5 | Height |
| BRCA | cis | rs13393800 | 1 | rs1307667 | chr2:233419972 | TIGD1 | chr2:233412779-233415226:- | -0.14 | -3.56 | 0.000381 | Height |
| BRCA | cis | rs2070488 | 1 | rs13079757 | chr3:38491444 | XYLB | chr3:38388251-38456467:+ | 0.19 | 5.45 | 6.36E-8 | Electrocardiographic conduction measures |
| BRCA | cis | rs10935120 | 1 | rs13081177 | chr3:134289860 | ANAPC13 | chr3:134196547-134204865:- | -0.4 | -13.04 | 3.4E-36 | Height |
| BRCA | cis | rs10935120 | 1 | rs13081177 | chr3:134289860 | CEP63 | chr3:134204575-134293852:+ | -0.14 | -3.68 | 0.000243 | Height |
| BRCA | cis | rs10935120 | 1 | rs13081688 | chr3:134259954 | ANAPC13 | chr3:134196547-134204865:- | -0.41 | -13.26 | 2.87E-37 | Height |
| BRCA | cis | rs10935120 | 1 | rs13081688 | chr3:134259954 | CEP63 | chr3:134204575-134293852:+ | -0.14 | -3.8 | 0.000155 | Height |
| BRCA | cis | rs3772130 | 1 | rs13083794 | chr3:121464928 | IQCB1 | chr3:121488610-121553926:- | 0.27 | 7.08 | 2.54E-12 | Cognitive performance |
| BRCA | cis | rs3772130 | 1 | rs13083794 | chr3:121464928 | SLC15A2 | chr3:121613171-121663034:+ | -0.13 | -3.86 | 0.00012 | Cognitive performance |
| BRCA | cis | rs9858542 | 1 | rs13085791 | chr3:49721798 | AMT | chr3:49454212-49460012:- | 0.1 | 3.38 | 0.000764 | Crohn's disease;Ulcerative colitis |
| BRCA | cis | rs9858542 | 1 | rs13085791 | chr3:49721798 | GMPPB | chr3:49758932-49761384:- | -0.13 | -3.9 | 0.000101 | Crohn's disease;Ulcerative colitis |
| BRCA | cis | rs13067306 | 1 | rs13087299 | chr3:94229344 | DHFRL1 | chr3:93776770-93782067:- | -0.18 | -4.16 | 3.39E-5 | Blood pressure measurement (high sodium intervention) |
| BRCA | cis | rs3772130 | 1 | rs13087578 | chr3:121369207 | IQCB1 | chr3:121488610-121553926:- | 0.28 | 7.14 | 1.76E-12 | Cognitive performance |
| BRCA | cis | rs3772130 | 1 | rs13087578 | chr3:121369207 | SLC15A2 | chr3:121613171-121663034:+ | -0.14 | -3.91 | 9.79E-5 | Cognitive performance |
| BRCA | cis | rs10935120 | 1 | rs13087875 | chr3:134261123 | ANAPC13 | chr3:134196547-134204865:- | -0.41 | -13.2 | 5.95E-37 | Height |